Professor Jean Aicardi

[Jean François Marie Aicardi (1926-2015)].

In memoriam Professor Jean-Antoine Rioux (1925-2017)

René Houin, Nicole Léger, Jean Dupouy-Camet, Patrick Bastien, and Gérard Luffau 1 Académie Vétérinaire de France, 34 rue Bréguet, 75011 Paris, France 2 UFR de Pharmacie, Université de Reims Champagne-Ardenne, 51096 Reims, France 3 Faculté de Médecine Paris Descartes, Paris, France 4 Département de Parasitologie-Mycologie, CHU de Montpellier/Faculté de Médecine, UMR “MiVEGEC” (CNRS 5290/IRD 224 ...

[Aicardi-Goutières syndrome].

INTRODUCTION Aicardi-Goutières syndrome (AGS) is an autosomal recessive encephalopathy characterized by acquired microcephaly, cerebral calcifications, leukodystrophy, cerebral atrophy and cerebrospinal fluid findings of chronic lymphocytosis and raised interferon-alpha (INF-alpha). The main extraneurological symptoms are chilblain-like skin lesions, usually on the fingers, toes and ears. SOU...

Aicardi-Goutières syndrome.

Aicardi-Goutieres syndrome is a familial progressive early onset encephalopathy with basal ganglia calcifications, chronic CSF lymphocytosis and high level of interferon-alpha in CSF. Cutaneous necrotic lesions and the neuropathological aspect of microangiopathy and microinfarctions suggest a vascular process in relation to elevated interferon-alpha. A genetic defect in the regulation of its sy...

Jean - Paul Fermand and Jean - Claude Brouet

In the majority o f chronic lymphocytic leukemias (CLL), proliferative B lymphocytes are thought to be frozen in vivo at a given maturat ion stage (1). Recently, several studies have emphasized that CLL cells could be driven to different iate into plasma cells in vitro (with or without proliferation) upon t r iggering by mitogens (2, 3, 4) or T cel l -der ived factors (5, 6). Th u s far, howeve...